Multidimensional mass-spectrometry for early detection of severe sepsis/septic shock in patients with neutropenic fever – a pilot study.

Multidimensional mass-spectrometry for early detection of severe sepsis/septic shock in patients with neutropenic fever – a pilot study. - Lab-ALERTS pilot

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00000647

Enrollment

120

Registered

2010-12-15

Start date

2010-12-10

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A41.9

Interventions

Group 1: Asservation of excess blood from routine blood sample during hospital stay. Analysis of blood samples before fever, at fever onset and following 4 days with masspectroscopy (SELDI-TOF).

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with haemato-oncological disease undergoing chemotherapy with anticipated period of neutropenia which agree to participate in the study

Exclusion criteria

Exclusion criteria: none

Design outcomes

Primary

Measure	Time frame
Identification of diagnostic signatures for early diagnosis of severe sepsis / septic shock	—

Secondary

Measure	Time frame
Assessing the prognostic value of newly identified molecular signatures in patients at high risk of developing severe sepsis/septic shock in comparison to currently available, conventional laboratory parameters and clinical risk factors	—

Countries

Germany

Contacts

Public ContactMichael Kiehntopf

Institut für Klinische Chemie und Laboratoriumsdiagnostik Center for Sepsis Control and Care (CSCC) Klinikum Lobeda

michael.kiehntopf@med.uni-jena.de+49 3641 9325000

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026