DEcompressive Surgery for the Treatment of malignant INfarction of the middle cerebral arterY – Registry

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00000624

Enrollment

1000

Registered

2011-02-14

Start date

2010-01-25

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I63.5

Interventions

Group 1: Observation group 1: Patients fullfilling the inclusion criteria treated with decompressive surgery Group 2: Observation group 2: Patients fullfilling the inclusion criteria treated conservat

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Clinical signs and symptoms of an unilateral infarction of the middle cerebral artery (MCA) 2. cCT: Evidence of an unilateral ischemic infarction of the MCA, involving at least 50% of the territory or more. 3. MRI: No evidence of a relevant mismatch 4. With or without involvement of ACA and PCA territory 5. Informed consent signed by patient or legal representative

Exclusion criteria

Exclusion criteria: Additional brain injury at the same time or contemporary (e.g. traumatic brain injury)

Design outcomes

Primary

Measure	Time frame
Death or severe disability after one year (mRS 5 or 6 vs. 0-4)	—

Secondary

Measure	Time frame
After 1 year 1. Disability using the modified Rankin Scale (mRS) 2. Quality of life using the EuroQoL 5-D 3. Depression using the Geriatric Depression Scale (GDS) 4. Surgical complications 5. Median survival and mortality 6. Treatment: Retrospective consent	—

Countries

Austria, Germany

Contacts

Public ContactMiriam Bauer

Centrum für Schlaganfallforschung Berlin- CSB

miriam.bauer@charite.de

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 25, 2026