F41.0 F40.01
Conditions
Interventions
Group 1: Cognitive Behavior Therapy (CBT)
6 Weeks/12 sessions
Sponsors
Klinik für Psychiatrie und Psychotherapie, UK SH, Campus Lübeck
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Age: 18-60 years Right handedness Panic disorder (with or without agoraphobia) according to DSM-IV as primary diagnosis PAS: 19 or greater
Exclusion criteria
Exclusion criteria: General exclusion criteria for MRI (www.mrsafety.com) Substance dependence or abuse Psychotic disorders Neurological disorders or history of brain trauma Severe chronic somatic disorders 24h before measurement: Alcohol, Nicotine, Sleep deprivation, Drugs and psychoactive substances, particularly tranquilizer, sleep medication (except of SSRI in a stable dose since 6 weeks) Control subjects: History of psychiatric disorders according to SCID screening
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical: Change of panic symptoms according to Panic and Agroraphobia Scale (PAS: total score) after 6 weeks/12 sessions of Behavior Therapy MR-Spectroscopy: Change of cortical GABA concentration (IU) after 6 weeks/12 sessions of Behavior Therapy Psychophysics: Change of visual surround suppression effect ('point of subjective equivalence' in %) after 6 weeks/12 sessions of Behavior Therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical: Symptom change according to Hamilton Anxiety Scale (HAM-A; total score) and Hamilton Depression Scale (HAM-D; total score) after 6 weeks/12 sessions of Behavior Therapy | — |
Countries
Germany
Contacts
Public ContactBartosz Zurowski
Klinik für Psychiatrie und Psychotherapie, UK SH, Campus Lübeck
Outcome results
None listed