R52
Conditions
Interventions
Group 1: Placebo (air applied via inhalation)
By use of a table of random numbers, patients will be allocated into one of the arms (1-3).
Group 2: Xenon (10%, applied via inhalation during surgery)
By use of a table of random numbers, patients will be allocated into one of the arms (1-3).
Group 3: Xenon (20%, applied via inhalation during surgery)
By use of a table of random numbers, patients will be allocated into one of the arms (1-3).
Sponsors
Klinik für Anästhesiologie
Universitätsklinkum Ulm
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: ASA physical status I and II (NYHA = 1), patients scheduled for elective abdominal hysterectomy at the University Hospital of Ulm
Exclusion criteria
Exclusion criteria: Excusion criteria are respiratory tract infections, obstructive sleep apnea, diabetes mellitus, any relevant renal, liver, or heart (including arterial hypertension) disease, a history of neurological or psychiatric disorders or of adverse reactions to anesthetics, gastroesophageal reflux disease, regular alcohol consumption, drug abuse or taking sedatives or long acting analgesic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intra- and postoperative opioid requirement (remifentanil, morphine); patients" subjective feeling of pain assessed 0.5, 3, 6, 12, and 24h postoperative using the well known numeric rating scale (NRS). | — |
Secondary
| Measure | Time frame |
|---|---|
| relevant side-effects (e.g. vomiting, increased sedation), economical aspects (e.g. xenon/opioid consumption) | — |
Countries
Germany
Contacts
Public ContactOliver Adolph
Klinik für Anästhesiologie Universitätsklinkum Ulm
Outcome results
None listed