Distal resection of the pancreas with or without covering of the pancreatic remnant

Distal resection of the pancreas with or without covering of the pancreatic remnant - DISCOVER

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

DRKS

Registry ID

DRKS00000546

Enrollment

150

Registered

2010-09-13

Start date

2010-12-12

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C25.2

Interventions

Group 1: After resection of the pancreatic tail by scalpel, the remnant is closed by single stiches. Afterwards, it is additional covered by use of autologous serous tissue (falciform ligament, jejuna

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: patients equal or older than 18 years planed for elective open distal pancreatectomie Informed consent.

Exclusion criteria

Exclusion criteria: contribution in an other clinical trial, signs for obstruction in the pancreatic head, immunsupressive medication (corticoids more than 40 mg corticoids each day, azathioprin)

Design outcomes

Primary

Measure	Time frame
postoperative pancreatic fistula on the criteria of the ISGPF (International Study Group on Pancreatic Fistula), messured by enzyme evaluations from the drainages and observation of the clinical course, folow up until postoperative day 40.	—

Secondary

Measure	Time frame
morbidity (wound infection, intraabdominal fluid collections, delayed gastric emptying (DGE, international definition), potspancreatectomie haemorhage (PPH, internaltional definition), occurence of burst abdomen, new onset diabetes mellitus), total operation time in minutes, frequence and kind of operative and interventional revisions, mortality (death of any cause until postoperative day 7), hospital- and intensive care stay in days, frequence of in-patient treatment after discharge, time until closure of a pancreatic fistula (missing excretion of enzyme-rich fluid), quality of life (EORTC-questionaire)	—

Measure

Time frame

morbidity (wound infection, intraabdominal fluid collections, delayed gastric emptying (DGE, international definition), potspancreatectomie haemorhage (PPH, internaltional definition), occurence of burst abdomen, new onset diabetes mellitus), total operation time in minutes, frequence and kind of operative and interventional revisions, mortality (death of any cause until postoperative day 7), hospital- and intensive care stay in days, frequence of in-patient treatment after discharge, time until closure of a pancreatic fistula (missing excretion of enzyme-rich fluid), quality of life (EORTC-questionaire)

—

Countries

Germany

Contacts

Public ContactMatthias Hassenpflug

Klinik für Allgemein-, Visceral- und Transplantationschirurgie

matthias.hassenpflug@med.uni-heidelberg.de+49/6221/56-37508

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 22, 2026