"The posttraumatic arthrosis of the hip joint after Acetabular Fracture"- Prospective study for evaluation of prognostic factors and their relevance to avoid hip arthrosis after acetabular fractures.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00000541

Enrollment

Registered

2010-09-01

Start date

2010-06-04

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M19.15

Interventions

Group 1: Operative treatment with open reduction and internal fixation of acetabular fracture and cartilage sampling.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: -Acetabulum fracture -No spinal cord injuries with neurological deficit

Exclusion criteria

Exclusion criteria: -Age <18y -Neurological deficit because of other reasons than acetabulum fractures -Existing coxarthrosis before injury -Femoral head necrosis -Systemic medication with corticosteroide -Chronic systemic inflammation disease

Design outcomes

Primary

Measure	Time frame
Prognostic marker after acetabular fractures Genetic studies with micro-RNA analysis (ASPN, AGC1, COL9A1, COL9A2, COL9A3, COK11A2, ESR1, FZRB, COL2A1, COL 1A1, MMP-3, IL1 gene cluster, etc.) Histological and biochemical analysis of cartilage Endpoint 2 years postoperatively.	—

Secondary

Measure	Time frame
Proteins and mediators in the serum (matrix metalloproteinases and inflammatory mediators, cytokines) 3,6,12 and 24 months postoperatively.	—

Countries

Germany

Contacts

Public ContactSabine Drum

Universitätsklinikum des Saarlandes Klinik für Unfall-, Hand- und Wiederherstellungschirurgie

sabine.drum@uks.eu06841 1622683

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026