We examined only healthy subjects Application for prevention and treatment of adiposity might be considered
Conditions
Interventions
Group 1: Intranasally administered insulin (6X 20 international units IU)
Group 2: Placebo
Sponsors
Universität Düsseldorf, Klinik für Endokrinologie, Diabetologie und Rheumatologie
Eligibility
Sex/Gender
Male
Age
20 Years to 30 Years
Inclusion criteria
Inclusion criteria: healthy male students
Exclusion criteria
Exclusion criteria: Diabetes (also parents and siblings), allergies, chronic and/or acute rhinitis, diseases and anatomic deviations of the nose, chronic diseases: i.e., cardiovascular disorders; endocrine disorders and neurological diseases, especially seizures, chronic diseases of liver and kidneys, and other chronic diseases; medication with glucocorticoids and psychopharmacological drugs, substance abuse (alcohol, drugs); smoking; athelets were excluded
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Food-intake behavior (calorie intake) as a reduction in a standardized test meal in the exreimental- compared to the control group; Blood glucose and peripheral insulin under euglycemia: Relative to baseline: cumulative change of blood glucose (11 measurement poits) and insulin (6 measurement points) in the experimental- compared to the control group | — |
Secondary
| Measure | Time frame |
|---|---|
| Peripheral leptin, cortisol, epinephrine, norepinephrine: Cumulative change of the hormones in the experimental- compared to the control group (measurement points see insulin) Memory: Scores in psychometric test (Lern- und Gedächtnistest LGT-3) in the experimental- compared to the control group; EEG: acousticall-evoked potentials in the experimental group compared to the control group (1 measuremnt point baseline, 3 meaurement points during intranasal treatment) | — |
Countries
Germany
Contacts
Public ContactUrsula Stockhorst
Universität Osnabrück Institut für Psychologie Allgemeine Psychologie II und Biologische Psychologie
Outcome results
None listed