Coronary artery bypass graft surgery in patients with asymptomatic carotid stenosis

Coronary artery bypass graft surgery in patients with asymptomatic carotid stenosis - CABACS

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

DRKS

Registry ID

DRKS00000521

Enrollment

316

Registered

2010-08-20

Start date

2010-12-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I25 I65.2

Interventions

Group 1: coronary artery bypass graft surgery without carotid endarterectomy Group 2: combined carotid artery bypass graft (CABG) surgery and carotid endarterectomy (CEA)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Key inclusion criteria: 1. Identification of a =80% stenosis (ECST criteria) of the extracranial carotid artery in a patient scheduled for coronary artery bypass graft (CABG) surgery with the stenosis being asymptomatic for the past 180 days 2. Carotid stenosis treatable with CEA 3. Written informed consent 4. Male or female patients of age =18 years

Exclusion criteria

Exclusion criteria: Key exclusion criteria: 1. Stenosis related neurological symptoms within the previous 180 days 2. Non-atherosclerotic origin of stenosis 3. NSTEMI within the past 48 hours, STEMI within the past 7 days or hemodynamically unstable patients 4. Modified Rankin Scale score >3 or severe aphasia

Design outcomes

Primary

Measure	Time frame
The primary efficacy endpoint is the event rate of nonfatal strokes or deaths from any cause (whatever occurs first) within 30 days after the intervention (either isolated CABG or synchronous CABG + CEA).	—

Secondary

Measure	Time frame
Secondary efficacy endpoints are single components of the primary endpoint, myocardial infarction, technical failures, duration of ventilatory support, change of cognitive performance on the Demtec scale and observations at different time points.	—

Countries

Czechia, Germany

Contacts

Public ContactStephan Knipp

Klinik für Thorax und kardiovaskuläre Chirurgie Universitätsklinikum Essen

stephan.knipp@uk-essen.de0201 723 84915

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026