J96.1 J44
Conditions
Interventions
Group 1: NPPV (PCV-mode) with calculated target volume (8ml/kg ideal body weight
ideal body weight=24 kg/m2).
Group 2: NPPV (PCV-mode) with pneumotachographically measured target volume (110% of daytime tidal volume under established conventional NPPV in PCV wihout target volume).
Sponsors
Universitätsklinikum Freiburg, Abteilung Innere Medizin V - Pneumologie
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: COPD patients with stable hypercapnic chronic respiratory failure (CRF) on NPPV (>3months) will be enrolled.
Exclusion criteria
Exclusion criteria: Patients who presented with an acute exacerbation (respiratory frequency >30 breaths/min, pH <7.30 or clinical signs of infection), those planned for weaning from invasive ventilation or those who had been intubated or tracheotomized during the previous 3 months will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sleep efficiency (comparison between NPPV with and without target volume) | — |
Secondary
| Measure | Time frame |
|---|---|
| sleep stages, nighttime events, alveolar ventilation at nighttime, subjective sleep quality and quality of life by questionnaires (comparison between NPPV with and without target volume) | — |
Countries
Germany
Contacts
Public ContactJan Hendrik Storre
Universitätsklinik Freiburg Innere Medizin V - Pneumologie
Outcome results
None listed