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Oxygenation during noninvasive ventilation: active valve- versus leak-circuit

Oxygenation during noninvasive ventilation: active valve- versus leak-circuit

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00000449
Enrollment
20
Registered
2010-10-05
Start date
2009-12-11
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

J96.1

Interventions

Group 1: active valve circuit with and without an artficial leak Group 2: leak circuit with and without an artficial leak

Sponsors

Universitätsklinikum Freiburg, Abteilung Innere Medizin V - Pneumologie
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: Patients with stable hypercapnic chronic respiratory failure (CRF) on NPPV with supplemental oxygen of at least 2 L/min will be enrolled. Patients are referred to the Department of Pneumology of the University Hospital Freiburg for a routine control visit of their NPPV.

Exclusion criteria

Exclusion criteria: Patients who presented with an acute exacerbation (respiratory frequency 30 breaths/min, pH <7.35 or clinical signs of infection), those planned for weaning from invasive ventilation or those who had been intubated or tracheostomised during the previous 3 months will be excluded.

Design outcomes

Primary

MeasureTime frame
Difference of FiO2 at FiO2-sensor 2 (at the interface) between active valve circuit and leak circuit

Secondary

MeasureTime frame
Mean transcutaneous PCO2, oxygen saturation (SaO2), Subjective ventilation quality

Countries

Germany

Contacts

Public ContactJan Hendrik Storre

Universitätsklinik Freiburg Innere Medizin V - Pneumologie

jan.storre@uniklinik-freiburg.de0049 761 270 3401

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 10, 2026