OPS 5-413 A41 D73.0 Q89.0
Conditions
Interventions
Group 1: patients with asplenia and sepsis
Group 2: patients without asplenia and sepsis
Sponsors
Zentrum für chronische Immundefizienz Freiburg (CCI)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Cases key inclusion criteria: - Community-acquired severe sepsis/septic shock - Sepsis start = 48 h prior hospitalization - History of splenectomy or proof of spenectomie through ultrasound or CT-scan - age = 18 years Controls key inclusion criteria: - Consecutive admission at the same Intensive Care Unit with community-acquired severe sepsis/septic shock - Sepsis start = 48 h prior hospitalization - No history of splenectomy or proof of existing spleen through ultrasound or CT-scan - age = 18 years - Similar age and same sex as case
Exclusion criteria
Exclusion criteria: missing informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients with OPSI due to S. pneumoniae compared to age and sex-matched cases with community-acquired severe sepsis/septic shock without splenectomy (comparison group) Determination through blood culture and pcr for pneumocoocus at study entry | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison cases versus controls (APACHE II Score , SOFA Score day 0, 1, 3, 3 and 7) Distribution of foci, distribution of pathogens apart from pneumococci 28-day mortality, and sepsis severity (days of ventilation an dialysis, days of admission to ICU and hospital) Charlson Comorbidity index, prognostic factors (indication for splenectomy, Underlying disease/comorbidity, immunosuppression and vaccination status etc) | — |
Countries
Germany
Contacts
Public ContactChristian Theilacker
CCI Zentrum für Infektiologie und Reisemedizin
Outcome results
None listed