hip fracture S72.00
Conditions
Interventions
Group 1: Blood samples of 36 ml blood are taken from patients pre operativey and within 12 hours after surgery.
Group 2: A blood sample of 36 ml is taken once from the probands.
Sponsors
Klinikum rechts der Isar, Technische Universität München
Eligibility
Sex/Gender
All
Age
75 Years to No maximum
Inclusion criteria
Inclusion criteria: inclusion criteria for the patients: -older than 75 years for group 1 and for group 2 older than 18 years and younger than 40 years -informed consent - hip fracture (group1) and fracture of a long bone (group2) respectively inclusion criteria for the probands: - older than 75 years for group 1 and for group 2 older than 18 years and younger than 40 years - informed consent - no fracture within the last twelve weeks
Exclusion criteria
Exclusion criteria: exclusion criteria for the patients and probands - younger than 18 years - pregnancy -open fractures -periprothetic fractures -polytrauma -patients with systemic infection diseases -tumours, radiochemotherapy -intake of drugs which could modulate the immune system like corticosteroids -patients/probands who cannot give their informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression levels of GRO- alpha and MCP-1 in the serum of patients older than 75 years with a hip fracture and with or without postoperative complications. These expression levels are analysed in the serum of blood sampley taken pre- and postoperatively. Complications are detected during the in-hospital stay of the patients. | — |
Secondary
| Measure | Time frame |
|---|---|
| Analysis of transcription factors (STAT, JNK) in granulocytes and monocytes. | — |
Countries
Germany
Contacts
Public ContactHelen Vester
Klinikum rechts der Isar, Abteilung für Unfallchirurgie, Technische Universität München
Outcome results
None listed