F42
Conditions
Interventions
Group 1: Cognitive-behavioral therapy (CBT) with in-vivo exposure and response prevention
Sponsors
Klinik für Psychiatrie und Psychotherapie Universitätsklinikum Schleswig-Holstein Campus Lübeck
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: - OCD diagnosis according to DSM-IV (SCID) - Y-BOCS total score of 16 or more - Illness duration of at least one year - Absence of psychoactive medication (at least 4 weeks wash-out) - Right handedness (according to EHI)
Exclusion criteria
Exclusion criteria: - Concurrent major depression - Acute Suicidality - Substance abuse or dependence (present and history of) - History of major head trauma - Major neurological and somatic illnesses - Pregnancy and lactation - Absence of contraception in fertile women - Concurrent participation in other clinical trials, including 30 days before enrollment - Generally accepted exclusion criteria for participation in MRI research (http://www.ismrm.org)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -Symptom Reduction (Yale-Brown-Obsessive-Compulsive Scale; Clinical Global Impression) - Cognitive Performance (Neuropsychological Test Battery) at T0 and T2 - Concentration of neurometabolites in the brain tissue (Proton Magnetic Resonance Spectroscopy; 1H-MRS) at T0 and T2 - Fractional Anisotropy of white matter of the brain (Diffusion Tensor Imaging; T0 and T2) - BOLD-Signal as measured with functional Magnetic Resonance Imaging (fMRI) during cognitive activation and rest | — |
Secondary
| Measure | Time frame |
|---|---|
| Change of depressive symptoms (Hamilton Depression Rating Scale and Beck Depression Inventory, at timepoints T0 and T2) | — |
Countries
Germany
Contacts
Public ContactAndreas Kordon
Klinik für Psychiatrie und Psychotherapie Universitätsklinikum Schleswig-Holstein Campus Lübeck
Outcome results
None listed