J44.8 J44.9
Conditions
Interventions
Group 1: In the COSYCONET Study the correlation between pulmonary disorders, comorbidities and systemic inflammation in patients with COPD would be observed in a cross sectional and longitudinal way.
Sponsors
Philipps-Universität Marburg
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: Diagnosis COPD (GOLD criteria) or chronic cough written informed consent cognitive and physical ability to meet the demands of the study protocol Available for repeated study visits over 18 months
Exclusion criteria
Exclusion criteria: Having undergone lung surgery (e.g. lung volumen reduction, lung transplant) Patients with lung cancer under treatment Moderate or severe exacerbation within the last 4 weeks Unable to walk or to understand the intention of the project
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main outcome will be the multidimensional BODE-Score: based on the Body-Mass-Index, FEV1, Dyspnoe (modified MRC-Scale),and the physical capacity (measured ny 6-minute-walk-test). The Bode-Score will be assessed at baseline, 6, 18, 36, 572, 90and 108 months after first visit in the study centres. Progression is defined as a change in BODE-Score by >=1 point over the observation period | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of hospitalization during the observation period: patients will be ask how often they were hospitalised in the last year (at baseline) or since the last visit (after 6, 18, 36, 54, 72, 90 and 108 months). All cause mortality rate: assessed by the study centres 6, 18, 36, 54, 72, 90 and 108 months after inlcusion. || Comorbidities: will be asked by the studycentres based on a list of diseases. The following examinations will be performed at each visite: Nutritional status: Bioimpedance, waist circumstance Labaratory tests: Lipid status, Haemoglobin, haematocrit, glucose, Markers of systemic inflammation and aging: IL-6, IL-8, TNF-alpha, firinogen, NT-NT-pro BNP, telomere lenght Cardiovascular diseases: ECG at rest, Echocardiographie at rest, Ankle-Arm-Index, Carotid artery intima-media thickness Quality of life: EQ-5D (Questionnaire) Depression: PHQ-D (Questionnaire) Cognitive impairement: (DemTec) physical activity: IPAQ (Questionnaire) | — |
Countries
Germany
Contacts
Public ContactSandra Söhler
Philipps-Universität Marburg Klinik für Innere Medizin mit Schwerpunkt Pneumologie Geschäftsstelle Kompetenznetz Asthma/COPD
Outcome results
None listed