F32 F33
Conditions
Interventions
Group 1: SSTR I/! (standardized stepwise drug treatment regimen):
lithium augmentation in step 2 in case of nonresponse to 4 weeks antidepressant monotherapy
steps of the treatment algorithm in case
Sponsors
Charité Universitätsmedizin Berlin, Campus Charité Mitte
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: major depressive episode, with or wíthout psychotic symtoms (ICD-10: F32.0, F32.1, F32.2, F32.3) recurrent depressive disorder, with or without psychotic symptoms (ICD-10: F33.0, F33.1, F33.2, F33.3, F33.8, F33.9) HAMD-score > 15 age 18-70 years informed consent
Exclusion criteria
Exclusion criteria: bipolar affective disorder (ICD-10: F31) depression caused by another medical condition, pregnancy/breastfeeding, pre-existing long-term medication treatment that could not be discontinued severe medical condition which presented a limitation for any of the possible treatments in the study admission by court order
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| time to remission (HAMD-21 < = 9 Punkte) HAMD: Hamilton Depression Rating Scale | — |
Secondary
| Measure | Time frame |
|---|---|
| - time to response (HAMD-reduction > 50%) - number of remitted patients (HAMD-21 50%) - number of strategy changes (switches) - duration of inpatient treatment - direct and indirect costs | — |
Countries
Germany
Contacts
Public ContactMazda Adli
Charité Universitätsmedizin, Campus Charité Mitte Klinik für Psychiatrie und Psychotherapie
Outcome results
None listed