muscle atropy, bone resorption, deconditioning of the cardio vascular system, deconditioning of the balance ability, cartilage degeneration
Conditions
Interventions
Group 1: Subject are immoblized for 14 days using 6° head down tilt bed rest. Twice a day they walk to the training room and stand for 5 x 1 minute on the turned off vibration platform. Inbetween the
Sponsors
Deutsches Zentrum für Luft- und Raumfahrt
Eligibility
Sex/Gender
Male
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: - healthy male subject - between 18 and 35 years - body weight: 75+/-10 kg - height: 180+/-10 cm - subjects that are willing and have the ability to participate in the whole study - negative skin prick test for sinistrin hypersensitivity - successfully pass the psychological and medical screening
Exclusion criteria
Exclusion criteria: -Abuse of drugs, medicine or alcohol (regular consumption of more than 20 - 30g alcohol / day) -Hyperlipidemia - Adipositas - kidney disorders -Participation in another study within 30 days before study onset -Blood donors in the past three months before the onset of the study -Smoker - Diabetes mellitus - Disposition for keloid -Rheumatic deseases - positive skin prick test for sinistrin hypersensitivity -Bone fractures or severe ligament injuries within one year prior to study onset -Use of metallic implants -Shoe size > 44 -No signed consent form before the onset of the experiment -Every other condition that, in the opinion of the head medical doctor, does not allow a participation in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Is vibration training able to decelerate or prevent muscle atrophy during 14 days of bed rest? || Changes in Biomarkers of bone metabolism (PINP, bone TRAP, bAP, Osteocalcin, CTX, NTX, Calcitriol) in blood and urine samples Data points: days -3 and -1 befor bed rest, days 2, 6, 8, 11, and 14 during bed rest, days R2 and R3 after bed rest. Blood sampling was performend after overnight fasting each morning at 7:00 am. 24-hour urine samples were collected for each study day || Changes in cartilage thickness of femur and tibia and concentration of biomarker cartialge oligometric matrix protein (COMP) in blood samples; Methods: magnet resonance imaging of the knee joint, biomarkers of cartilage metabolism in blood samples, Data points magnet resonance imaging: study days -1 before bed rest and R1 after bed rest. Data points blood samples: study days -3 and -1 before bed rest, study days 2, 6, 8, 11 and 14 during bed rest, study days R2, R3 and R5 after bed rest. Blood sampling was performed at 7:00 am after overnight fasting. || Changes in balance performance; Method: Investigation of the balance performance using the Posturomed device; Data points: day -4 before bed rest and day R 1 after bed rest. | — |
Countries
Germany
Outcome results
None listed