Critically ill internal patients, who need parenteral nutrition during the first seven days of acute illness
Conditions
Interventions
Group 1: normocaloric nutrition (100% of the measured or calculated energy expenditure)
Group 2: hypocaloric nutrition (50% of measured or calculated energy expenditure)
Sponsors
Universitätsklinikum Leipzig AöR, Department für Innere Medizin, Interdisziplinäre Internistische Intensivmedizin
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: critically ill medical patients, which require artificial nutrition for at least three days
Exclusion criteria
Exclusion criteria: - underweight patients (defined as a body mass index of less than 19) or pre-existent malnutrition - refusal to participate in the study by the patient or guardian - probable length of ICU stay less than 3 days - no need for artificial nutrition - pregnancy - immune suppression - transplantation - chemotherapy - surgical patients - burns - age under 18 years or over 80 years - participation in another trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of nosocomial infection (microbiological diagnosis of tracheal secretion, urin and blood culture, clinical and radiological criteria of nosocomial infection) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Glycemic control and insulin demand (Blood glucose control every 3 hours, documentation of insulin demand to maintain a blood glucose level of 8-10 mmol/l) - intensive care unit survival - hospital survival - 28-day survival Data acquistion from hospital charts, telephone interview if patient discharged before day 28 (questionnaire) | — |
Countries
Germany
Contacts
Public ContactLorenz Weidhase
Department für Innere Medizin und Dermatologie Interdisziplinäre Internistische Intensivmedizin
Outcome results
None listed