Effect of antidepressants on the activity of stress-responsive systems

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

DRKS

Registry ID

DRKS00000008

Enrollment

120

Registered

2008-09-05

Start date

2003-04-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F32 F33

Interventions

Group 1: Mirtazapin Group 2: venlafaxine

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: major depression (DSM-IV) Hamilton Depression Rating Scale-21 item version: at least 18

Exclusion criteria

Exclusion criteria: bipolar depression Depression due to an organic or substance factor substance dependency lifetime diagnosis of schizophrenia glucocorticoid therapy

Design outcomes

Primary

Measure	Time frame
Hamilton Depression Rating Scale: <8 = remission -50% = response	—

Countries

Germany

Contacts

Public ContactMichael Deuschle

Zentralinstitut für Seelische Gesundheit

michael.deuschle@zi-mannheim.de+49 621 1703 2331

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 29, 2026