Obesity
Conditions
Interventions
Normal-Weight Reference Group:None
Gastric Bypass Stenting Group:None
GLP-1 Receptor Agonist Therapy Group:None
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Age 18–60 years. 2.Body mass index (BMI) = 28 kg/m² for the intervention groups; BMI 18.5–23.9 kg/m² for the normal-weight reference group. 3.Based on clinical evaluation, participants were assigned to one of the following groups: sleeve gastrectomy, gastric bypass stenting, GLP-1 receptor agonist therapy, or a normal-weight reference group, and met the corresponding eligibility criteria for each group. 4.Willingness to participate and provision of written informed consent prior to enrollment.
Exclusion criteria
Exclusion criteria: 1.Age <18 years or =60 years; 2.BMI =28 kg/m² for the intervention groups, or BMI outside the range of 18.5–23.9 kg/m² for the reference group; 3.Failure to meet the inclusion criteria for any of the four study groups. 4.Presence of contraindications to any of the assigned interventions. 5.History of neurological disorders (e.g., stroke, brain tumor, epilepsy) or traumatic brain injury. 6.Contraindications to MRI examination (e.g., metallic implants, cardiac pacemaker, claustrophobia). 7.Severe dysfunction of major organs, including heart, liver, or kidney (e.g., Child–Pugh class C, estimated glomerular filtration rate [eGFR] <30 mL/min/1.73 m², New York Heart Association [NYHA] class IV). 8.Pregnancy or lactation. 9.Severe psychiatric disorders (e.g., schizophrenia, bipolar disorder) or cognitive impairment (Mini-Mental State Examination [MMSE] score <24). 10.Participation in other interventional clinical studies within the past 3 months. 11.Any other conditions deemed by the investigators to render the participant unsuitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain function MRI (fMRI) indicators: changes in brain area activation related to tasks (food craving), changes in resting-state functional connectivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive and behavioral assessments;biochemical and multi-omics analyses;tissue analyses;Gastric ultrasonography;psychological scale evaluations; | — |
Countries
China
Contacts
Public ContactBu Le
Shanghai Tenth People's Hospital
Outcome results
None listed