PONV after thyroidectomy
Conditions
Interventions
Group U:Aprepitant combined with ondansetron
Sponsors
The Second People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients aged 18 to 65 years with ASA physical status ?–? who underwent elective thyroidectomy (including partial, subtotal and total thyroidectomy) under general anesthesia, volunteered to participate, and were accessible for postoperative follow-up and assessment;
Exclusion criteria
Exclusion criteria: 1.Patients with uncontrolled severe underlying diseases; 2.patients with a history of PONV or motion sickness, or preoperative nausea and vomiting; 3.patients allergic to study drugs or their excipients; 4.patients receiving glucocorticoids, 5-HT3 receptor antagonists, NK-1 receptor antagonists, anticholinergics, antihistamines or other known antiemetic medications within one week before surgery; 5.pregnant or lactating women; 6.patients with poor compliance unable to complete follow-up; 7.and other conditions deemed ineligible by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of PONV within 24 hours after surgery;Proportion of patients with nausea, vomiting or retching meeting diagnostic criteria; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse drug reactions;Severity of PONV;Antiemetic efficacy rate; | — |
Countries
China
Contacts
Public ContactYing Zhao
The Second People's Hospital
Outcome results
None listed