Age-related macular degeneration
Conditions
Interventions
Control group:None
Sponsors
Department of Ophthalmology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai,China
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. People aged 50 and above; 2. Lesions such as hemorrhage, exudation and drusen appear in the macular area on fundus photography; 3. Proliferative choroidal neovascularization, inter-retinal or sub-retinal fluid accumulation are observed on OCT, and fluorescence leakage and CNV vascular morphology can be seen on FFA and ICGA; 4. All the enrolled patients had never received intravitreal injection therapy before.
Exclusion criteria
Exclusion criteria: 1. Any history of macular pathology unrelated to nAMD; 2. The equivalent spherical refractive error exceeds 6 diopters of myopia; 3. Any previous intraocular surgery has been performed (such as pars plana vitrectomy of the ciliary body, glaucoma surgery, corneal transplantation or radiotherapy), etc.; 4. The included eye has a history of idiopathic or autoimmune-related uveitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The methylation level of miRNA in the intraocular fluid; | — |
Secondary
| Measure | Time frame |
|---|---|
| Optimal corrected vision; | — |
Countries
China
Contacts
Public ContactKe Mao
Department of Ophthalmology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai,China
Outcome results
None listed