Urothelial Carcinoma
Conditions
Interventions
Index test:Detection of free mitochondrial DNA mutation rate in urine supernatant using single-primer amplification-based library preparation combined with high-throughput sequencing
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age 18 years or older; 2.Clinically diagnosed with urothelial carcinoma requiring surgery; 3.Clinical stage T1-2N0M0; 4.No residual disease evidence on postoperative imaging; 5.Patient signed informed consent;
Exclusion criteria
Exclusion criteria: 1.Patients with other active malignancies or severe complications; 2.Patients with distant metastasis; 3.Insufficient tumor tissue for MRD testing; 4.Patients undergoing total cystectomy;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Free mitochondrial DNA mutation rate in urine supernatant;Accuracy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity;Specificity; | — |
Countries
China
Contacts
Public ContactBi Hai; Han Bangmin; Lou Jiatao
Shanghai General Hospital
Outcome results
None listed