Catheter-related bladder discomfort (CRBD)
Conditions
Interventions
Esketamine combined with oxycodone group:Esketamine combined with oxycodone
Sponsors
Tianjin First Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years; 2.American Society of Anesthesiologists (ASA) physical status I–III; 3.Scheduled for elective transurethral surgery; 4.Voluntarily provided written informed consent;
Exclusion criteria
Exclusion criteria: 1.Preoperative indwelling urinary catheter; 2.Pre-existing overactive bladder, urinary tract infection, neurogenic bladder, or other related conditions; 3.Long-term use of sedatives, analgesics, or psychotropic drugs; 4.History of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or intracranial hypertension; 5.History of opioid or ketamine abuse; 6.Severe hepatic or renal insufficiency (Child-Pugh class C, eGFR < 30 ml/min); 7.Severe cardiovascular and cerebrovascular diseases (e.g., unstable angina, myocardial infarction within the past 6 months, severe heart failure with EF < 40%); 8.Pre-existing hyperthyroidism, pheochromocytoma, or other relevant conditions; 9.Any other conditions deemed unsuitable for participation by the investigator or attending physician;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of CRBD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of Life QoR15;Sleep quality;Incidence of delirium;Incidence of CRBD by grade at each time point;Pain; | — |
Countries
China
Contacts
Public ContactYu Wenli
Tianjin First Central Hospital
Outcome results
None listed