After a stroke, 70% to 80% of patients are unable to live independently due to physical disabilities, which greatly impacts their quality of life and imposes a substantial social burden. The recovery of walking function is a crucial goal for achieving independent living.
Conditions
Interventions
Healthy Control Group:No
Sponsors
The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. According to the diagnostic criteria for various cerebrovascular diseases issued by the Chinese Society of Neurology, stroke patients confirmed by head CT or MRI are eligible for inclusion. Each enrolled patient is required to undergo an MRI examination. The inclusion criteria are as follows: 2. disease duration between 2 weeks and 2 years; 3. age 18-80 years; 4. Brunnstrom motor function stage 2-5; 5. Mini-Mental State Examination (MMSE) score > 24, indicating good cognitive status and normal verbal communication or the ability to follow motor commands, with willingness to cooperate; 6. sitting balance grade 2 or above; 7. conscious and alert, with a Glasgow Coma Scale (GCS) score of 15.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of three or more episodes of ischemic or hemorrhagic brain injury; 2. patients with severe clinical comorbidities or complications such as coronary heart disease, angina pectoris, heart failure, atrial fibrillation or other severe arrhythmias, lower limb venous thrombosis, pulmonary embolism, or severe mental disorders; 3. patients with a history of severe motor, balance, cognitive, or speech function impairments; 4. conditions that significantly affect inflammatory indicators, such as severe infections, immunosuppression, use of glucocorticoids, or severe liver and kidney damage; 5. patients with incomplete clinical data; 6. individuals with conditions such as aphasia, visual impairment, or hearing problems, as well as those lost to follow-up; 7. those who have not signed the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Facial Action Units; | — |
Secondary
| Measure | Time frame |
|---|---|
| FNIRS;Berg Balance Scale;Fatigue Severity Scale;A Super;EEG;National Institutes of Health Stroke Scale;Fugl-Meyer motor function;FMRI;SEMG;EAD;Brunnstrom;NRS;Montreal Cognitive Assessment;NIHSS;HADS;SF-12; | — |
Countries
China
Contacts
Public ContactWu Ming
The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
Outcome results
None listed