concomitant esotropia,concomitant exotropia
Conditions
Interventions
Sponsors
Eye Hospital, Wenzhou Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Inclusion Criteria for the Concomitant Esotropia Group: (1) A definite diagnosis of concomitant esotropia (including congenital or early-onset esotropia) and meeting the surgical indications; (2) The clinical surgical plan requires recession or resection of the lateral rectus muscle, and the distal resected tissue of the lateral rectus muscle can be obtained intraoperatively; (3) Age of 6 months or older, with no gender restriction; (4) The patient or the patient's legal guardian fully understands the study content and has signed the informed consent form. 2. Inclusion Criteria for the Concomitant Exotropia Group: (1) A definite diagnosis of concomitant exotropia (including intermittent exotropia or constant exotropia) and meeting the surgical indications; (2) The clinical surgical plan requires recession or resection of the medial rectus muscle, and the distal resected tissue of the medial rectus muscle can be obtained intraoperatively; (3) Age of 6 months or older, with no gender restriction; (4) The patient or the patient's legal guardian fully understands the study content and has signed the informed consent form. 3. Normal Control Group: (1) The tissue source is extraocular muscles obtained from organ donors meeting ethical requirements; (2) Available data indicate no history of strabismus, extraocular muscle surgery, orbital diseases, thyroid-associated ophthalmopathy, myasthenia gravis, neuromuscular disorders, or other conditions that may affect the structure and function of extraocular muscles in the donors; (3) Priority is given to the collection of horizontal rectus muscles matching those of the case groups, including the lateral rectus and medial rectus muscles; the lateral rectus is used to match the lateral rectus group of concomitant esotropia, and the medial rectus is used to match the medial rectus group of concomitant exotropia; (4) Donor age, sex, eye laterality, cause of death, tissue procurement time, preservation conditions, and available ocular and systemic history information should be recorded as completely as possible, and will be used as quality control parameters or covariates in subsequent analyses.
Exclusion criteria
Exclusion criteria: 1.Exclusion Criteria 1. Those who have previously received botulinum toxin injection, ocular radiotherapy, or extraocular muscle surgery; 2. Those with concurrent thyroid-associated ophthalmopathy, myasthenia gravis, orbital tumors, orbital inflammation, ocular trauma involving the extraocular muscles, or other diseases that may affect the structure or function of extraocular muscles; 3.Those with incomitant strabismus, such as paralytic strabismus, restrictive strabismus, Duane syndrome, or congenital cranial dysinnervation disorders; 4.Those with concurrent severe systemic infection, severe immune disorders, active malignancy, or other conditions deemed by the investigator to be unsuitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| differentially expressed genes;Baseline differences between the normal control group and the strabismus groups: similarities and differences in cell states, differential pathways, and genetic enrichment patterns; | — |
Countries
China
Contacts
Public ContactWan Minghui
Eye Hospital, Wenzhou Medical University
Outcome results
None listed