Postherpetic neuralgia(PHN)
Conditions
Interventions
Sponsors
Zigong First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 90 eligible subjects aged 18-75 were divided into 3 groups, with 30 subjects in each group; 1. PHN(Postherpetic neuralgia) Group: Pain persists for more than 1 month after healing of the shingles rash, with a VAS score of >=4 points; 2. Acute Herpes Zoster(AHZ) Group: Patients with a clear history of herpes zoster, where the rash has not completely healed within 1 month of onset (e.g., during the crusting or erythematous phase). 3. Healthy Control Group (HC): Healthy volunteers matched for age and gender;
Exclusion criteria
Exclusion criteria: 1.Combine individuals with severe hematological diseases, autoimmune diseases, malignant tumors, and long-term users of immunosuppressants; 2.Severe infections, major surgeries, or blood transfusion history within the past 1 month; 3.Pregnant and lactating women. 4.Those with abnormal coagulation function or severe anemia who are unable to have venous blood drawn; 5.Individuals with mental disorders who are unable to understand and sign informed consent on their own and have no legal representative to accompany them; 6.Reject blood specimen outsourcing for third-party testing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gene expression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Protein expression;Pain score;Pain sensitivity of animals after modeling;Overall m6A modification and glycolysis level of spinal cord tissue in model animals; | — |
Countries
China
Contacts
Public ContactLiu Qian
Zigong First People's Hospital
Outcome results
None listed