Postoperative Delirium (POD)
Conditions
Interventions
Sponsors
Yantai Yuhuangding Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years; 2.Scheduled to undergo elective or semi-elective non-cardiac surgery at our center; 3.Anesthesia plan includes general anesthesia, either total intravenous anesthesia or combined intravenous-inhalation anesthesia; 4.ASA physical status I–III; expected duration of surgery >= 2 hours; 5.Preoperatively alert and able to complete MoCA, CFS, HADS-A and other preoperative assessments; 6.Written informed consent obtained from the patient or their legally authorized representative;
Exclusion criteria
Exclusion criteria: 1.Preoperative Montreal Cognitive Assessment (MoCA) score below 15; 2.Pre-existing diagnosis of dementia, severe neurological disorders, or severe psychiatric illnesses that may interfere with cognitive assessment, informed consent, or postoperative delirium assessment; 3.Cerebral infarction, cerebral hemorrhage, or other acute central nervous system events within 3 months before surgery; 4.Long-term regular use of benzodiazepines, non-benzodiazepine sedative-hypnotics, or other centrally acting sedatives for > 3 months prior to surgery,which may confound interpretation of midazolam exposure or postoperative delirium assessment; 5.Severe hearing, visual, or language impairment that precludes completion of the scale assessments; 6. Severe hepatic or renal insufficiency that, in the investigator's judgment, may significantly affect perioperative sedative metabolism or study safety; 7.Pre-existing delirium, acute disturbance of consciousness, or significant psychiatric/behavioral abnormalities before surgery; 8.Clear anticipation that no postoperative delirium assessment can be completed, or that postoperative data will be unobtainable; 9. Concurrent participation in another clinical study that may affect the exposure, outcomes, or interpretation of this study; 10.Other conditions deemed inappropriate for enrollment by the investigator;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Completion rate of the complete research chain;Incidence of postoperative delirium within 7 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospital length of stay;Midazolam utilization rate and administration pattern;Preoperative cognitive stratification;PACU length of stay; | — |
Countries
China
Contacts
Public ContactJin Jin
Yantai Yuhuangding Hospital
Outcome results
None listed