Atrial fibrillation
Conditions
Interventions
Ciprofol group:Anesthesia Induction with Ciprofol
Sponsors
THE SECOND PEOPLE'S HOSPITAL,WUHU
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 65 years old, regardless of gender; 2. Preoperatively confirmed diagnosis of atrial fibrillation, with concomitant left ventricular diastolic dysfunction verified by echocardiography; 3. American Society of Anesthesiologists (ASA) physical status classification II-III; 4. Scheduled for elective non-cardiac surgery under general anesthesia; 5. Well-controlled preoperative blood pressure: systolic blood pressure < 160 mmHg and diastolic blood pressure < 100 mmHg; 6. Voluntary written informed consent signed by the patient or legal representative.
Exclusion criteria
Exclusion criteria: 1. Left ventricular ejection fraction < 50% with severe left ventricular systolic dysfunction; 2. Acute heart failure or myocardial infarction within the past 3 months; 3. Atrial fibrillation combined with third-degree atrioventricular block or sick sinus syndrome, with a cardiac pacemaker implanted or pending implantation; 4. History of allergy to propofol, ciprofol and other anesthetics used in this study; 5. Combined severe hepatic and renal insufficiency (Child-Pugh Class C, renal failure requiring dialysis); 6. Coagulopathy or active bleeding tendency; 7. Mental illness or cognitive dysfunction that prevents cooperation with the study and follow-up visits; 8. Pregnant or breastfeeding women; 9. Emergency surgery, major vascular surgery, or estimated operation duration exceeding 6 hours; 10. Use of investigational drugs affecting cardiovascular function within the past 1 month, or current participation in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypotension during anesthesia induction;Systolic blood pressure, diastolic blood pressure, heart rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bispectral index (BIS) value;Onset time of anesthesia induction, intubation condition score;Incidence of adverse reactions including bradycardia, hypertension, coughing, nausea and vomiting;Postoperative recovery time and tracheal extubation time; | — |
Countries
China
Contacts
Public ContactYing Zhao
THE SECOND PEOPLE'S HOSPITAL,WUHU
Outcome results
None listed