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Clinical study on predicting preeclampsia in chronic hypertension

Clinical study on predicting chronic hypertension complicated preeclampsia with using maternal sFlt-1/PIGF and fetal cfDNA

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600131241
Enrollment
Unknown
Registered
2026-08-31
Start date
2026-09-10
Completion date
Unknown
Last updated
2026-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preeclampsia

Interventions

Sponsors

Beijing Obstetrics and Gynecology Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 51 Years

Inclusion criteria

Inclusion criteria: 1. Primary hypertension combined with pregnancy and singleton pregnancy; 2. Primary hypertension pregnancy was diagnosed through internal medicine consultation, with no major organ complications and no pregnancy contraindications; 3. Voluntarily participate in this study.

Exclusion criteria

Exclusion criteria: 1. Secondary hypertension such as renal parenchymal hypertension, primary aldosteronism, pheochromocytoma, Cushing's syndrome, and hypertension caused by aortic constriction; 2. Fetal malformation; 3. Refuse to participate in this study.

Design outcomes

Primary

MeasureTime frame
High-risk factors for diseases;The cutoff values for predicting PE associated with chronic hypertension, based on serological levels of sFlt-1, PIGF, the sFlt-1/PIGF ratio, and fetal cfDNA.;

Secondary

MeasureTime frame
General conditions during pregnancy;Laboratory test results;Concurrent preeclampsia;Maternal complications;Neonatal complications;

Countries

China

Contacts

Public ContactWu Shaowen

Beijing Obstetrics and Gynecology Hospital, Capital Medical University

w810925@163.com+86 10 52273699

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Sep 19, 2026