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Screening and Optimization of Targeted Bioactive Peptides against Major Pathogens of Peri-implantitis

Screening and Optimization of Targeted Bioactive Peptides against Major Pathogens of Peri-implantitis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600131205
Enrollment
Unknown
Registered
2026-08-31
Start date
2026-09-01
Completion date
Unknown
Last updated
2026-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

peri-implantitis

Interventions

Peri-implant health group:None

Sponsors

School of Stomatology, the Fourth Military Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Age: 18-75 years; 2. Those who have implanted at least one implant in our department and have undergone crown or bridge repair; 3. The jaw position relationship is basically normal. ,"1.""2.","?""?""(1)""(2)".:"="">=","="""">","= 6 mm; 3. Radiographic examination shows that the most coronal bone level around the implant is >= 3 mm from the implant platform. Diagnostic Criteria for Peri-implant Health All of the following conditions must be met: 1. No clinical signs of inflammation; 2. Mild probing shows no bleeding or pus; 3. No increase in probing depth compared to previous examinations; 4. No additional bone loss beyond changes caused by initial bone remodeling; 5. A single bleeding spot around the implant is allowed (referencing the ID-COSM 2023 consensus update).

Exclusion criteria

Exclusion criteria: 1. Patients with uncontrolled systemic diseases, including but not limited to diabetes mellitus (HbA1c > 7%), uncontrolled hypertension, immunodeficiency disorders, or chronic use of glucocorticoids or immunosuppressants; 2. Patients received periodontal or implant periodontal treatment within 3 months; 3. Patients who have taken antibiotics and microecological preparations within 4 weeks; 4. Patients who are pregnant or breastfeeding; 5. Patients smoking =10 cigarettes per day; 6. Patients with other active infectious lesions in the oral cavity.

Design outcomes

Primary

MeasureTime frame
Depth of probing around implant ;Peri-implant bleeding index ;Bone loss around implants ;

Countries

China

Contacts

Public ContactMin Tian

School of Stomatology, The Fourth Military Medical University

64761465@qq.com+86 29 8477 2455

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Sep 19, 2026