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Antibiotic Effects on Gut Function and Microbiota in Critically Ill ICU Patients: An Observational Study

A Prospective Observational Study on Antibiotic Exposure and Its Impact on Gut Function and Inflammatory Responses in Critically Ill ICU Patients

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600131107
Enrollment
Unknown
Registered
2026-08-28
Start date
2026-09-01
Completion date
Unknown
Last updated
2026-08-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critical illness / Gut dysfunction / Gut microbiota dysbiosis

Interventions

ICU patients:None

Sponsors

Qingdao University Shanghai Clinical School of Medicine / Shanghai Deji Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age >= 18 years 2. ICU length of stay >= 72 hours 3. Expected to receive systemic antibiotics for >= 3 days 4. Presence of nasogastric tube or accessible faecal sampling

Exclusion criteria

Exclusion criteria: 1. Bowel surgery within 7 days prior to ICU admission 2. Active gastrointestinal bleeding 3. Inflammatory bowel disease or short bowel syndrome 4. Pregnancy or breastfeeding

Design outcomes

Primary

MeasureTime frame
Incidence of clinically significant gut dysfunction;Gut microbiota alpha diversity;Relative abundance of Enterobacteriaceae;—

Secondary

MeasureTime frame
Duration of inflammatory plateau phase;Incidence of antibiotic escalation; Incidence of secondary infection;—

Countries

China

Contacts

Public ContactLiang Tian

Qingdao University Shanghai Clinical School of Medicine / Shanghai Deji Hospital (Department of Pharmacy)

til777@foxmail.com+86 182 1767 7718

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Sep 19, 2026