Adipose aging and multi-organ aging
Conditions
Interventions
Generally healthy older adults:None
Sponsors
Second Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
Male
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: 1:Han Chinese males. 2:Young group: age 20–30 years; Elderly group: age >=65 years. 3:The overall health status is good, as confirmed through medical history taking and physical examination. 4:No antibiotics, probiotic preparations, or health supplements containing prebiotics have been taken within the past 1 month. 5:No history of severe chronic diseases, such as diabetes mellitus, neurological disorders (e.g., Alzheimer's disease, Parkinson's disease), cardiovascular or cerebrovascular diseases, or malignant tumors. 6:Non-smokers. 7:Voluntarily participate in the study and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1:Diagnosis of known organic intestinal disorders (e.g., inflammatory bowel disease, irritable bowel syndrome, colorectal cancer, etc.). 2:Has undergone gastrointestinal surgery within the past 1 month. 3:Patients with severe hepatic or renal insufficiency. 4:Long-term use of medications that may affect the gut microbiota, such as immunosuppressants, glucocorticoids, or proton pump inhibitors. 5:History of acute infection, diarrhea, or constipation within the past 1 month. 6:History of alcohol or drug abuse. 7:Other circumstances in which the investigator deems the subject unsuitable for participation in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fecal microbiota;Fecal metabolites;Peripheral Blood Leukocyte Telomere Length; | — |
Countries
China
Contacts
Public ContactChai Renjie
Second Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed