Autism
Conditions
Interventions
High-Risk (HR) Children for ASD group:Assessment
Sponsors
Children's Hospital,Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
1 Years to 3 Years
Inclusion criteria
Inclusion criteria: 1.Group A: Children with Autism Spectrum Disorder (ASD) (1) Aged 1–3 years; (2) Clinically evaluated by an attending physician in the rehabilitation department and meeting the diagnostic criteria for Autism Spectrum Disorder as outlined in the DSM-5; (3) Assessment results from the Autism Diagnostic Observation Schedule (ADOS) consistent with an ASD diagnosis; (4) No confirmed hearing impairment or other severe physical diseases; (5) The child's legal guardian is fully informed and voluntarily agrees to participate in this study, having signed a written informed consent form. 2.Group B: Children at High Risk of Autism (1) Aged between 1 and 2 years; (2) Having a family history of ASD, or being clinically assessed by at least one attending physician in rehabilitation medicine as being at developmental risk (e.g., language delay, abnormal social interaction, etc.); (3) Having no confirmed hearing impairment or other severe physical diseases; (4) The child's legal guardian is fully informed, voluntarily agrees to participate in this study, and has signed a written informed consent form. 3.Group C: Typically Developing Children (TDC) (1) Aged 1–3 years; (2) Clinically assessed by an attending physician in the rehabilitation department to have no neurodevelopmental disorders or significant developmental delays; (3) No definite hearing impairment or other severe physical diseases; (4) The child's legal guardian is informed and voluntarily agrees to participate in this study, with a signed written informed consent form.
Exclusion criteria
Exclusion criteria: 1.Exclusion Criteria (Exclusion if any of the following applies) (1) Presence of a definite hearing impairment or severe visual impairment that affects the ability to complete basic audio-visual tasks. (2) Co-morbid severe neurological or physical diseases (e.g., epilepsy, brain injury, genetic metabolic diseases) that may interfere with the study measurements. (3) Inability to complete the basic experimental tasks during the study due to emotional state, health conditions, or compliance issues. (4) The guardian disagrees or withdraws informed consent at any stage of the study. (5) Other conditions deemed by the investigators as inappropriate for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain Functional Measures;Modified Checklist for Autism in Toddlers Score;Autism Diagnostic Observation Schedule Score;Autism Behavior Checklist Score;Self-Rating Anxiety Scale Score;Self-Rating Depression Scale Score;Parenting Stress Index-Short Form Score; | — |
Countries
China
Contacts
Public ContactChenyu Yan
Children's Hospital,Zhejiang University School of Medicine
Outcome results
None listed