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Immediate Analgesic and Sustained Effects of Manual Release Combined with Therapeutic Ultrasound on Myogenic Temporomandibular Disorders: A Randomized, Sham-Controlled, Assessor-Blinded Clinical Trial

Immediate Analgesic and Sustained Effects of Manual Release Combined with Therapeutic Ultrasound on Myogenic Temporomandibular Disorders: A Randomized, Sham-Controlled, Assessor-Blinded Clinical Trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600130722
Enrollment
Unknown
Registered
2026-08-24
Start date
2026-08-28
Completion date
Unknown
Last updated
2026-08-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Temporomandibular joint disorders (TMD)

Interventions

experimental group:Ultrasound combined with manual therapy

Sponsors

The Fourth People's Hospital of GuiYang
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1.meeting the diagnosis of "myalgia" according to Axis ? of the internationally recognized Diagnostic Criteria for Temporomandibular Disorders (DC/TMD); 2. aged 18 to 40 years; 3. presenting with unilateral masticatory muscle pain as the primary complaint, with a Numerical Rating Scale (NRS) score for pain during chewing >=3; 4. disease duration >= 1 month; 5. able to comprehend the content of the questionnaires and cooperate in completing all assessments.

Exclusion criteria

Exclusion criteria: 1. patients with a primary diagnosis of disc displacement, arthralgia, or degenerative joint disease; 2.those with systemic rheumatic or autoimmune diseases such as rheumatoid arthritis or ankylosing spondylitis; 3. those with a history of maxillofacial trauma, tumor, or surgery; 4. those who had received physical therapy, nerve block, or acupuncture targeting the temporomandibular joint region within the past month; 5.those with local skin damage, infection, or contraindications to ultrasound therapy; 6.pregnant or lactating women; 7. those with severe psychiatric disorders or cognitive impairment.

Design outcomes

Primary

MeasureTime frame
NRS score;

Secondary

MeasureTime frame
Patient Global Impression of Change;JFLS-8 score;Resting NRS Score;Mandibular movement function;Responder rate;Pressure Pain Threshold (PPT) and Difference Between Healthy and Affected Sides (?PD);Masticatory function;Fricton Temporomandibular Joint Dysfunction Index;Opening Deviation;Maximum Voluntary Opening (MMO) Pain-Free Maximum Opening (PF-MMO) Maximum Passive Opening;

Countries

China

Contacts

Public ContactYang Shuifen

The Fourth People's Hospital of GuiYang

565979411@qq.com+86 851 85967482

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Sep 19, 2026