hypoxemia, anxiety, agitation, poor tolerance, and hypoxia-related discomfort
Conditions
Interventions
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years; 2. Admitted to the ICU for clinical management between January 2022 and July 2024; 3. Received intravenous sedation with ciprofol or propofol during the ICU stay, with a single or cumulative duration >= 2 hours (allowing cumulative interruptions <= 30 minutes); 4. Were undergoing non-invasive respiratory support at the initiation of sedation, including NIV, HFNC, or conventional nasal cannula/mask oxygen therapy; 5. Had complete and continuous electronic medical record documentation of the following: RASS scores; vital signs (respiratory rate, SpO2, blood pressure, heart rate, etc.); sedative medication regimen (dose, administration method, adjustment details); respiratory support mode and its changes over time.
Exclusion criteria
Exclusion criteria: 1.Pregnant or lactating women; 2.Concurrent or prior use of other major sedatives, such as midazolam or dexmedetomidine; 3.Cumulative use of ciprofol or propofol 30% (including sedation depth [RASS scores], vital signs, medication records, etc.); 6.Patients who received invasive mechanical ventilation (endotracheal intubation) prior to enrollment or with unclear airway management records; 7.Participation in other interventional clinical trials that may interfere with the assessment of study outcomes; 8.Severe hearing or vision impairment, coma, altered consciousness, or other conditions that may significantly affect data collection and accurate RASS assessment; 9.Patients deemed unsuitable for participation by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of respiratory depression;sedation success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| ICU length of stay (ICU LOS);use of vasopressors;ICU mortality;overall intubation rate; | — |
Countries
China
Contacts
Public ContactZhenhua Zeng
Southern Medical University Southern Hospital
Outcome results
None listed