Asymmetric Hearing Loss, AHL
Conditions
Interventions
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 - 60 years old; 2. The score of the Montreal Cognitive Assessment Scale, after adjusting for years of education, is >= 26 points, and the individual can independently or under the guidance of the researcher complete the research process; 3. Has the ability to understand Mandarin; 4. Voluntarily participates in this study and signs the written informed consent approved by the ethics committee. A. Normal Hearing Group: 1. Self-reported normal hearing, without hearing-related complaints; 2. Pure tone audiometry of both ears (0.5, 1, 2, 4 kHz) with average air conduction pure tone threshold (Pure Tone Average, PTA) = 70 dB HL, while the PTA on the unaffected side at these frequencies is = 15 dB HL; 2. Apart from hearing, other physiological and intellectual developments are basically normal, and there are no known language, cognitive, or motor impairments or previous brain injuries.
Exclusion criteria
Exclusion criteria: 1. Have active external otitis, otitis media, acute attack of Meniere's disease, diagnosed acoustic neuroma or other definite structural lesions of the central auditory pathway; 2. Have a history of epilepsy, uncontrolled severe vertigo, stroke, Parkinson's disease, severe anxiety disorder or depression, etc., neurological or mental psychological diseases; 3. Have contraindications for magnetic resonance examination, such as implanted non-compatible cardiac pacemakers, cochlear implants, nerve stimulators, ferromagnetic implanted devices like metal aneurysm clips in the body, or those with severe claustrophobia and unable to cooperate with long-term lying still scans; 4. Pregnant women, lactating women or those planning to get pregnant; 5. Participate simultaneously in other interventional clinical trials that may affect audiological or cognitive function assessment; 6. Have poor compliance and cannot cooperate with electrophysiological tests, functional magnetic resonance imaging examinations and later follow-up; 7. The investigator judges that there are any other situations that may affect the safety of the study, data quality or the rights and interests of the subjects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lateralization Index of Target Speech Neural Tracking; | — |
Secondary
| Measure | Time frame |
|---|---|
| Association Between Neural Indices and Clinical Auditory or Cognitive Measures;Attended–Ignored Speech Neural Tracking Difference;Behavioral Comprehension Accuracy During Speech Listening; | — |
Countries
China
Contacts
Public ContactZhang Ke
Peking University Third Hospital
Outcome results
None listed