Knee osteoarthritis
Conditions
Interventions
Sponsors
Foshan Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for the KOA group: (1) Meet the diagnostic criteria for KOA, meet the surgical indications, and undergoing total knee replacement; (2) Be informed and sign the informed consent form. 2. Inclusion criteria for the healthy control group: (1) Aged 40-75 years, with gender matched to the KOA group; (2) No history of chronic knee pain, no clinical symptoms such as knee swelling or limited mobility; (3) No history of knee injury or surgery; (4) No history of inflammatory joint diseases such as rheumatoid arthritis or gouty arthritis; (5) Be informed and sign the informed consent form. 3. Inclusion criteria for the normal control group: (1) Patients undergoing knee amputation due to trauma or arthroscopic surgery due to non-inflammatory, non-osteoarthritis conditions such as meniscus tears or intra-articular loose bodies; (2) Be informed and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Combined with other knee joint diseases, such as rheumatoid arthritis, gouty arthritis, septic arthritis, joint tuberculosis, pigmented villonodular synovitis and other inflammatory or tumor-like lesions; 2. Previous history of severe trauma to the knee joint (such as intra-articular fractures, complete ligament rupture, etc.) or lower limb surgery (this item is absolutely excluded in the healthy control group, and those with a history of distal surgery unrelated to the current knee joint may be included in the KOA group and normal cartilage control group as appropriate); 3. In the past 3 months, have a history of intra-articular injection (glucocorticoids, sodium hyaluronate, etc.); 4. Long-term use of glucocorticoids, immunosuppressants and other drugs that may affect bone metabolism or ferroptosis pathways (continuous use for >=3 months); 5. Combined with severe metabolic diseases (such as uncontrolled diabetes, hyperparathyroidism, etc.), autoimmune diseases, malignant tumors or severe liver and kidney insufficiency; 6. Those with contraindications to MRI examination or unable to cooperate in completing the research process.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Fe2+, MDA, and GSH levels; | — |
Secondary
| Measure | Time frame |
|---|---|
| Morphological changes in cartilage tissue;Expression and localization of Nrf2, HO-1 and GPX4 proteins in cartilage tissue;VAS pain score, WOMAC knee function score and Kellgren-Lawrence imaging classification;Nrf2, HO-1 and GPX4 gene and protein expression in cartilage tissue; | — |
Countries
China
Contacts
Public ContactWang Yi
Foshan Hospital of Traditional Chinese Medicine
Outcome results
None listed