Chronic Insomnia
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age range: 18 - 65 years old (inclusive of 18 and 65); 2. The insomnia patient group met the diagnostic criteria for insomnia disorder as per DSM-5; the healthy control group had no complaints of insomnia and their PSQI score was <= 5 points. 3. Not using antibiotics or probiotic preparations for the past 4 weeks; 4. Be able to complete questionnaire and scale assessments; 5. Voluntary signing of the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe physical diseases (such as tumors, immune system disorders, severe gastrointestinal diseases, etc.); 2. Severe mental disorders (such as schizophrenia, bipolar disorder, depression with suicidal risk, mental retardation, dementia, etc.); 3. Other insomnia caused by severe sleep disorders (such as severe sleep apnea, restless legs syndrome, circadian rhythm disorders, etc.); 4. Patients with active oral diseases (such as severe periodontitis, oral mucosal diseases, etc.); 5. Pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| flora; | — |
Countries
China
Contacts
Hangzhou Seventh People's Hospital