Postoperative Delirium
Conditions
Interventions
Non-decay group:None
Sponsors
The Affiliated Hospital of Qingdao University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age >=18 years, scheduled to undergo allogeneic liver transplantation (including deceased donor liver transplantation and living donor liver transplantation) at our hospital. 2. Preoperative cognitive function is normal (MMSE score: >=17 for illiterate individuals, >=20 for primary school education, and >=24 for middle school education or above). 3. Able to cooperate with preoperative ultrasound-based sarcopenia, frailty, and cognitive function assessments. 4. Informed consent obtained and signed by the patient or their legally authorized representative.
Exclusion criteria
Exclusion criteria: 1. Preoperatively diagnosed with cognitive impairment, dementia, psychiatric disorders (e.g., depression, schizophrenia, etc.), or neurological diseases (e.g., cerebral hemorrhage, cerebral infarction, intracranial tumors, etc.). 2. Preoperative presence of severe hepatic encephalopathy (grade III or above) or impaired consciousness. 3. Presence of lesions in the target muscle for assessment (e.g., muscle tumors, severe myositis, unhealed muscle tears after trauma, etc.) that may affect ultrasound evaluation results. 4. Prior history of organ transplantation or malignant tumors (except for patients with primary hepatocellular carcinoma who underwent liver transplantation without distant metastasis). 5. Severe infection, massive hemorrhage, or acute cardiovascular or cerebrovascular events within 2 weeks before surgery. 6. Pregnant or breastfeeding women. 7. Severe communication impairments (e.g., hearing or speech disorders) that prevent cooperation with scale assessments, or a history of long-term preoperative opioid dependence. 8. Refusal to participate in this study or inability to complete postoperative follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pretransplant frailty status;Preoperative cognitive function;Preoperative sarcopenia status;The levels of indicators such as CRP, IL-6, and TNF-a;Tube removal time;Time off the ventilator;ICU stay time;Complications that occur within 30 days after surgery; | — |
Countries
China
Contacts
Public ContactLiu Aijie
The Affiliated Hospital of Qingdao University
Outcome results
None listed