Benign gallbladder diseases requiring elective laparoscopic cholecystectomy, including cholelithiasis and gallbladder polyps
Conditions
Sponsors
Sir Run Run Hospital, Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years, with a body mass index (BMI) > 18 kg/m^2 and < 28 kg/m^2; 2. American Society of Anesthesiologists (ASA) physical status I-III and scheduled for elective laparoscopic cholecystectomy under general anesthesia at Sir Run Run Hospital, Nanjing Medical University; 3. Either sex; 4. Requiring overnight hospitalization after surgery; 5. Voluntarily participating in the study and providing written informed consent.
Exclusion criteria
Exclusion criteria: 1.Severe respiratory, cardiovascular, renal, or hepatic dysfunction diagnosed before surgery. 2.A history of stroke within the previous 6 months or other diagnosed central nervous system diseases. 3.A history of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or other psychiatric disorders. 4.A history of alcohol abuse or psychoactive substance dependence. 5.Unable to communicate adequately because of severe visual, hearing, or language impairment. 6.A history of allergy to opioids or contraindications to sufentanil, such as a history of severe respiratory depression or muscle rigidity. 7.Pre-existing cognitive impairment before surgery. 8.Participation in another drug clinical trial within 1 month before the scheduled surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Right diaphragmatic excursion after extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to extubation;Resting visual analogue scale (VAS) pain score;Arterial partial pressure of carbon dioxide (PaCO2);Postoperative nausea and vomiting (PONV);Peripheral oxygen saturation (SpO2);Arterial blood pH;Perioperative adverse events;Postoperative rescue analgesia;Heart rate (HR)?Mean arterial pressure (MAP); | — |
Countries
China
Contacts
Public ContactXiaoyu Liu
Sir Run Run Hospital, Nanjing Medical University
Outcome results
None listed