Developmental Coordination Disorder
Conditions
Interventions
Control group:sham stimulation
Sponsors
Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
3 Years to 12 Years
Inclusion criteria
Inclusion criteria: Healthy Children: 1. Age 3-12 years old (inclusive), any gender; 2. Right-handed (confirmed by a simplified handedness questionnaire); 3. DCDQ score > 57 (or above the 15th percentile for age norms); 4. MABC-2 total score above the 15th percentile; 5. SDQ score =8 years old) gives verbal consent; 9. Able to cooperate and complete an MRI scan (lying still for about 25-30 minutes). Children with DCD: 1. Age 3-12 years old (inclusive), any gender; 2. Right-handed (confirmed by a simplified handedness questionnaire); 3. DCDQ score = 17; 6. CBCL T-score >= 70; 7. CSHQ-CH-R >= 44; 8. Guardian signs the informed consent form, child (>=8 years old) gives verbal consent; 9. Able to cooperate and complete an MRI scan (lying still for about 25-30 minutes).
Exclusion criteria
Exclusion criteria: 1. History of epilepsy, or a first-degree relative with idiopathic epilepsy; 2. Abnormal electroencephalography (EEG) findings; 3. Presence of intracranial or intraocular metal implants; 4. Intracranial structural abnormalities; 5. Wearing non-removable metal dental braces; 6. Currently taking medications that lower the seizure threshold; 7. History of head trauma with loss of consciousness > 5 minutes; 8. Prior history of intracranial surgery; 9. Presence of non-removable metal objects in the body; 10. History of claustrophobia; 11. Unable to remain still during MRI scanning; 12. Requiring sedation to complete MRI; 13. Diagnosed neurological disorders (e.g., cerebral palsy, epilepsy, muscular dystrophy, intellectual disability, etc.); 14. Severe uncorrected visual or auditory impairments; 15. Currently receiving other interventional treatments (e.g., physical/occupational therapy, transcranial electrical stimulation, etc.); 16. Participation in another clinical trial within 3 months prior to enrollment; 17. Judged by the investigator to be unable to comply with the study procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Movement Assessment Battery for Children - Second Edition Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Resting-state fMRI functional connectivity;DCDQ score;Sleep efficiency;Motor Fluency;Child Behavior Checklist score;SDQ score;3D T1 structural brain region volume;Children's Sleep Habits Questionnaire – Chinese Revised Version score;The rate of glucose and oxygen consumption by the brain;Postural Stability;Distribution and concentration of neurotransmitters such as glutamate and GABA; | — |
Countries
China
Contacts
Public ContactWang Guanghai
Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed