Renal Cell Carcinoma complicated with Inferior Vena Cava Tumor Thrombus
Conditions
Interventions
Neoadjuvant therapy failure group:None
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years and <= 80 years; 2. Postoperatively pathologically confirmed renal cell carcinoma (RCC, any histological subtype); 3. Presence of inferior vena cava (IVC) tumor thrombus (Mayo grade I–IV) confirmed by preoperative contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI); 4. Underwent radical nephrectomy combined with inferior vena cava tumor thrombectomy (RN-IVCT); 5. Complete perioperative surgical records and key indicators of surgical difficulty were available; 6. For the neoadjuvant therapy group: received at least 2 cycles or 6 weeks of systemic therapy prior to surgery, with definitive baseline and preoperative imaging assessment reports; 7. For the upfront surgery group: did not receive any systemic therapy from diagnosis to surgery.
Exclusion criteria
Exclusion criteria: 1. Bilateral renal cell carcinoma, solitary kidney, or horseshoe kidney malformation; 2. Underwent palliative surgery (without primary tumor resection / incomplete tumor thrombus removal) or nephron-sparing surgery (NSS); 3. Assessed as complete response (CR) or partial response (PR) after neoadjuvant therapy, which falls outside the study scope of failed neoadjuvant downstaging; 4. Patients who abandoned surgery due to progressive disease (PD) or other reasons during or after neoadjuvant therapy (this subgroup will be described separately and will not be included in the comparison of surgical difficulty); 5. Severely incomplete clinical data (missing key surgical indicators or absence of > 20% of matching variables); 6. Concurrent other malignancies that affect surgical decision-making.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative challenging events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Major short-term postoperative complications;Postoperative length of stay;Postoperative ICU admission;Complete tumor thrombus removal rate; | — |
Countries
China
Contacts
Public ContactXin Ma
Chinese PLA General Hospital
Outcome results
None listed