coronary heart disease disorder of lipid metabolism inflammatory markers metabolic markers
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed with acute coronary syndrome (ACS), including ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI), and unstable angina (UA). All diagnoses were established in accordance with relevant guideline criteria. 2.The interval between two coronary angiographies was >=12 months. 3.At least three valid LDL-C measurements were available from baseline to follow-up for the calculation of cumulative LDL-C exposure. 4.At least three valid systolic blood pressure (SBP) measurements were available from baseline to follow-up for the calculation of SBP-TTR (time-in-therapeutic-range). 5.Complete baseline laboratory data including routine blood tests (neutrophil, lymphocyte, monocyte and platelet counts), lipid profiles (TC, TG, LDL-C, HDL-C), and fasting blood glucose, which were required to derive NLR, SII, PIV, MHR, AIP and TyG index.
Exclusion criteria
Exclusion criteria: 1.Patients with familial hypercholesterolemia (genetically confirmed or DLCN score > 8 points); 2.Patients who underwent the initial coronary angiography within 30 days after ACS onset; 3.Patients complicated with severe hepatic or renal insufficiency (eGFR 3 × ULN), malignant tumors, hematological diseases, autoimmune diseases, or acute infection; 4.Patients with a prior history of coronary artery bypass grafting (CABG); 5.Patients lost to follow-up due to non-cardiovascular causes or without complete follow-up data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| coronary lesion progression between two coronary angiographies; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cumulative LDL Exposure;Systolic Blood Pressure TTR;Correlation Between the NLR, SII, PIV, MHR, AIP, and TyG Indices and Disease Progression; | — |
Countries
China
Contacts
Public ContactJiang Yinong
The First Affiliated Hospital of Dalian Medical University
Outcome results
None listed