Target disease: Preeclampsia (PE), including severe and non-severe cases Related condition: Gestational hypertension (GH), as a high-risk precursor to PE
Conditions
Interventions
Sponsors
Shanghai Jiao Tong University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion Criteria for Healthy Pregnant Women and Patients: Age between 18 and 40 years; Gestational age between 20 and 38 weeks; Singleton pregnancy; Signed informed consent. Patient Inclusion Criteria: Based on the Guidelines for the Diagnosis and Treatment of Hypertensive Disorders in Pregnancy (2020). Gestational Hypertension (GH): Defined as new-onset hypertension after 20 weeks of gestation, with systolic blood pressure (SBP) >= 140 mmHg and/or diastolic blood pressure (DBP) >= 90 mmHg; Negative for proteinuria. Severe GH: SBP >= 160 mmHg and/or DBP >= 110 mmHg. Preeclampsia (PE): Defined as blood pressure > 140/90 mmHg and proteinuria >= 300 mg in a 24-hour urine collection. Severe Preeclampsia: SBP > 160 mmHg or DBP > 110 mmHg, and proteinuria > 5 g/24 hours, plus one or more of the following: Intrauterine growth restriction (IUGR) below the 10th percentile; Persistent neurological symptoms (headache, visual disturbances); HELLP syndrome: hemolysis, elevated liver enzymes (>2× normal), oliguria ( 1.0 mg/dL, or platelet count < 100,000 cells/µL.
Exclusion criteria
Exclusion criteria: 1. Pregnant women with multiple gestations; 2. Presence of severe reproductive system abnormalities or lesions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic performance of the urinary protein panel; | — |
Secondary
| Measure | Time frame |
|---|---|
| Differential expression of individual proteins; | — |
Countries
China
Contacts
Public ContactShao Wenguang
Shanghai Jiao Tong University
Outcome results
None listed