hyperuricemia
Conditions
Interventions
Experimental Group (Probiotic Intervention Group):Probiotic Intervention
Sponsors
The Fifth Affiliated Hospital , Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18–65 years, regardless of sex. 2.Meeting the diagnostic criteria for hyperuricemia: serum uric acid levels exceeding the physiological saturation threshold, defined as >420 µmol/L (7 mg/dL) in men and postmenopausal women, and >360 µmol/L (6 mg/dL) in premenopausal women. 3.Disease status and medical history: patients with or without a history of gout are eligible. Patients with a history of gout must not be experiencing an acute gout attack at enrollment, and more than 2 weeks must have elapsed since the last acute attack. 4.No use of antibiotics, live microbial preparations, or other microbiota-modulating products within 1 month before enrollment. 5.No history of gastrointestinal or cardiovascular diseases, and no abnormalities in liver or kidney function. 6.Provide signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients experiencing an acute gout attack. 2.Known allergy to any component of the probiotic preparation. 3.Participation in another clinical trial within the previous 3 months. 4.Use of antibiotics or probiotics within 1 month before study initiation. 5.Serious or unstable cardiac, hepatic, renal, hematologic, endocrine, malignant, or other major underlying diseases. 6.Severe psychiatric or neurological disorders that may prevent participants from complying with or completing the study. 7.Women who are pregnant, breastfeeding, or planning to become pregnant during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in serum uric acid levels from baseline to the end of treatment.; | — |
Secondary
| Measure | Time frame |
|---|---|
| inflammatory and oxidative stress biomarkers;liver and kidney function parameters;clinical symptoms and quality of life (the number of acute gout attacks);Proportion of participants achieving the target serum uric acid level;changes in metabolic parameters (lipid profile and blood glucose);gut microbiota composition; | — |
Countries
China
Contacts
Public ContactQiulong Yan
The Fifth Affiliated Hospital , Southern Medical University
Outcome results
None listed