Diabetic retinopathy
Conditions
Interventions
ERM Group:None
Sponsors
The Second Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients aged over 18 years who receive treatment at the Department of Ophthalmology, the Second Affiliated Hospital of Harbin Medical University, between January 2025 and December 2026 will be enrolled in this study. In the DR group, all patients will undergo best-corrected visual acuity testing, intraocular pressure measurement, slit-lamp examination of the anterior segment, fundus examination using a non-contact fundus lens, and optical coherence tomography (OCT). Fundus fluorescein angiography (FFA) will be performed in patients whose retinopathy stage is difficult to determine based on routine examinations. According to the International Clinical Diabetic Retinopathy Disease Severity Scale, patients with moderate to severe non-proliferative diabetic retinopathy (NPDR) accompanied by diabetic macular edema (DME) involving the foveal center will be included based on comprehensive findings from non-contact fundus lens examination, color fundus photography, OCT, and FFA. These patients are currently receiving intravitreal conbercept treatment. The ERM group will serve as the control group and will include age-matched patients undergoing surgery for epiretinal membrane, with normal blood pressure, blood glucose, and blood lipid levels. Written informed consent will be obtained from all participants before enrollment.
Exclusion criteria
Exclusion criteria: 1.Systemic exclusion criteria: patients with a history of malignant tumors, stroke, atherosclerosis, allergic diseases, connective tissue disease, myocardial infarction, severe hepatic or renal dysfunction, or acute infection. Ocular exclusion criteria: patients with concomitant keratitis, scleritis, glaucoma, uveitis, high myopia, or other fundus diseases were excluded. Patients with proliferative diabetic retinopathy who met the criteria for vitrectomy were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Copper ion concentration measurement and detection of cuproptosis-related molecules; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in inflammatory factor levels.;Imaging examination; | — |
Countries
China
Contacts
Public ContactJiang Bo
The Second Affiliated Hospital of Harbin Medical University
Outcome results
None listed