Early Subjective Cognitive Decline (SCD)
Conditions
Interventions
Control group :None
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Inclusion Criteria for the Patient Group (Based on the "Expert Consensus on the Diagnostic Process and Standards for Subjective Cognitive Decline in the Preclinical Stage of Alzheimer's Disease in China"): (1) Impairment is in the memory domain, not other cognitive domains; (2) Onset within the past five years, with a sustained self-experienced decline in cognitive ability compared to previous normal state, unrelated to acute events; (3) Han ethnicity, right-handed, age of onset >=50 years; (4) Concern or worry related to subjective cognitive decline; (5) Feeling that performance is worse than peers of the same age; (6) Does not meet the criteria for mild cognitive impairment: in at least one cognitive domain, both test scores are impaired (defined as below 1 standard deviation adjusted for age); the Functional Activities Questionnaire score >=9. According to Professor Frank Jessen's criteria for subjective cognitive decline, only those who report memory decline and have concerns about it are further tested for beta-amyloid. 2. Inclusion Criteria for the Healthy Group (due to limitations in objective follow-up and participant compliance, this study was unable to collect APOEepsilon4 genotype for the entire sample): (1) MMSE and MoCA scores must be strictly within the normal range; (2) Using specific subjective cognitive decline scales (e.g., SCD-Q or SCD-9), baseline scores should not indicate any subjective cognitive decline; (3) Combined with the Geriatric Depression Scale (GDS) and anxiety assessment to exclude false cognitive impairments caused by mood fluctuations; (4) High-resolution T1-3D structural image reverse screening: before enrollment or during image preprocessing, two senior radiologists perform a visual rating of medial temporal lobe atrophy (MTA) based on high-resolution T1 structural images. Any healthy participant with mild or greater medial temporal lobe atrophy, abnormal hippocampal volume reduction, or noticeable whole-brain cortical degeneration is excluded, maximizing the removal of hidden cognitive impairment from a neuro-morphological standpoint.
Exclusion criteria
Exclusion criteria: 1. Has a history of central nervous system diseases such as stroke, brain tumor, Parkinson's disease, encephalitis, etc. 2. Suffers from systemic diseases such as syphilis, thyroid dysfunction, severe anemia, AIDS, etc. 3. Has severe visual impairment (even after correction, unable to recognize color pictures), severe hearing loss or tactile insensitivity. 4. Upper limbs and shoulder-neck joints have limited movement, unable to perform imitation actions or button reaction. 5. Has a history of mental illness, congenital developmental delay or cognitive impairment caused by traumatic brain injury. 6. Is in an acute infection, fever state or at the end stage of a serious disease. 7. Pregnant or lactating women. 8. Has a body weight of more than 150 kilograms, unable to fit the experimental chair and equipment. 9. Has undergone shoulder-neck and upper limb surgery in the recent 3 months and has not fully recovered. 10. Engages in occupations or activities that may cause metal fragments to accidentally enter the body. 11. Has claustrophobia or is unable to cooperate to complete the entire experimental process (including practice and formal experimental stages).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mesoscopic scale local VASO-Beta value; | — |
Secondary
| Measure | Time frame |
|---|---|
| Macroscopic neuroimaging analysis of the whole-brain network activation; | — |
Countries
China
Contacts
Public ContactJun Hu
Peking University Shenzhen Hospital
Outcome results
None listed