Periodontitis
Conditions
Interventions
Sponsors
Stomatology Hospital,Zhejiang University School Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Experimental group: 1) Age >=18 years; 2) Diagnosed with generalized anxiety disorder based on clinical DSM-5 criteria at the Department of Psychosomatic Medicine, Hangzhou Seventh People's Hospital; 3) HAMA score >= 18; 4) Signed informed consent; 5) Agreed to the collection of saliva, subgingival, and blood samples and the completion of questionnaires in accordance with the SOP. 2.Control group: 1) age >=18 years; 2) recruited from the Department of Implantology at the Affiliated Stomatological Hospital of Zhejiang University School of Medicine, with no history of psychiatric disorders such as anxiety or depression; 3) GAD score <=4; 4) signed informed consent; 5) agreed to the collection of saliva, subgingival, and blood samples and the completion of questionnaires in accordance with the SOP.
Exclusion criteria
Exclusion criteria: 1.Recent use (within the past 3 months) of systemic antibiotics, systemic corticosteroids, or immunosuppressants; 2. Recent receipt (within the past 6 months) of systemic periodontal therapy or periodontal surgery; 3. Pregnant or lactating women; 4. Current severe systemic disease (e.g., active malignancy, severe hepatic or renal insufficiency); 5. Inability to complete the sampling protocol as required (e.g., failure to adhere to fasting requirements for saliva sampling); 6. Absence of natural teeth, preventing subgingival saliva sampling; 7. Current smokers or those who have quit smoking for less than one year; 8. Severe substance abuse (e.g., alcohol or drugs); 9. Severe cognitive impairment rendering the patient unable to understand informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| High-throughput sequencing data of gingival crevicular fluid and saliva; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical oral examination;Hematological, immunological, and cortisol markers; | — |
Countries
China
Contacts
Public ContactYang Guoli
Stomatology Hospital,Zhejiang University School Medicine
Outcome results
None listed