Subjective tinnitus
Conditions
Interventions
Control group:Sham repetitive transcranial magnetic stimulation
Sponsors
The FIrst Affiliated Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Age >= 18 years; 2) No gender restrictions; 3) Subjective tinnitus (a "sound experience perceived by the patient without an external sound source," which cannot be directly heard or recorded by others) lasting >= 6 months, with a THI score >= 38; 4) Concurrent anxiety symptoms with a HAMA score of =15, or concurrent depressive symptoms with a HAMD-17 score of >=8; 5) Able to cooperate with scale assessments, acoustic matching tests, and EEG recording; 6) The participant and legal guardian are willing to cooperate with treatment and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1) Unilateral or bilateral hearing loss >= 60 dB 2) Presence of an organic cause that explains tinnitus symptoms, such as chronic otitis media, conductive hearing loss, sudden hearing loss, active Meniere’s disease, or pulsatile tinnitus; 3) Significant suicidal ideation (Item 3 of the HAMD-17 scale >= 2 points); 4) Risk of seizures or a family history of epilepsy; 5) Contraindications for transcranial magnetic stimulation or MRI, such as the presence of metal or electronic devices in the body (e.g., intracranial metal foreign bodies, cochlear implants, pacemakers, stents, or other metallic foreign bodies); 6) Severe central nervous system disorders, such as brain tumors/space-occupying lesions, stroke, severe traumatic brain injury, neurodegenerative diseases, or a history of brain surgery; 7) Other uncontrolled systemic diseases, such as severe cardiac, pulmonary, hepatic, or renal insufficiency, or uncontrolled thyroid disorders; 8) Pregnant or breastfeeding women, or women of childbearing age with a positive urine pregnancy test; 9) Individuals who have received targeted treatment for tinnitus within the past 4 weeks, such as psychotherapy, acoustic tinnitus masking devices, or hearing aids; 10) Individuals who have undergone TMS or other neurostimulation therapies within the past 6 months, or who have participated in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| THI score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Scales for Measuring Emotions and Sleep-Related Factors;THI ;Psychoacoustic Assessment;Neurophysiological Outcomes;Safety Assessment; | — |
Countries
China
Contacts
Public ContactZhang Zhili
The FIrst Affiliated Hospital, College of Medicine, Zhejiang University
Outcome results
None listed