Primary Nephrotic Syndrome
Conditions
Interventions
Kidney biopsies-MCD:NA
Kidney biopsies-FSGS:NA
PNS:NA
Kidney biopsies-Adjacent non-tumor:NA
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
3 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Disease Group: Patients diagnosed with Primary Nephrotic Syndrome (PNS) and hospitalized in our institution. Diagnostic criteria for PNS include: (1) Massive proteinuria: 24-hour urinary protein excretion >=50 mg/kg, or a urine protein-to-creatinine ratio (mg/mg) >=2.0 in morning urine samples, with qualitative urinalysis showing (+++ to +++) on three consecutive morning specimens; (2) Hypoalbuminemia: serum albumin level below 25 g/L; (3) Hyperlipidemia: serum cholesterol exceeding 5.7 mmol/L; (4) Varying degrees of edema. Criteria (1) and (2) are mandatory for diagnosis (Chinese Journal of Pediatrics 2017 55(10):738-742. Pediatr Nephrol. 2023 Mar 38(3):877-919). 2. Control Group: The subjects of this study were pediatric patients who were hospitalized for urological tumors and underwent nephrectomy in the urology department of our hospital; the remaining urine samples after physical examination from patients who underwent health examinations in our hospital were used in this study.
Exclusion criteria
Exclusion criteria: 1. Concurrent history of other renal diseases and secondary nephrotic syndrome, such as IgA nephropathy or congenital nephrotic syndrome; 2. Documented history of other immunologically relevant disorders, including but not limited to asthma, systemic lupus erythematosus, and rheumatoid arthritis; 3. Control group: Presence of renal-related conditions or abnormal urinalysis findings.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| concentration of CD2AP protein;concentration of Myosin 9 protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| The distribution pattern of CD2AP;The distribution pattern of Myosin 9; | — |
Countries
China
Contacts
Public ContactYou Hui
Children's Hospital of Chongqing Medical University
Outcome results
None listed